US Secretary of State Hillary Clinton met Prime Minister Manmohan Singh at his 7, Race Course Road residence here Monday evening.
Clinton, who reached here from Kolkata Monday afternoon, will also be meeting Congress chief Sonia Gandhi.
She will meet External Affairs Minister S.M. Krishna Tuesday.
The two sides are expected to discuss a host of global issues, including Afghanistan and Iran, and the progress in implementing their bilateral civil nuclear deal, officials said.
The talks are expected to set the stage for the India-US strategic dialogue in Washington next month.