Holmes, who filed for divorce after five years of marriage, citing "irreconcilable differences", seeks sole custody of the couple's six-year-old daughter Suri.
Experts believe she will get a huge amount of money as child support from Cruise.
"Most of the estate is Tom's. She'll have to go for a lot of child support. She'll have to show that Suri has nannies, cars, activities, clothes, hair appointments. That a hefty amount each month is needed to maintain Suri's lifestyle," top divorce attorney Vikki Ziegler told Hollywoodlife.com.
Once the divorce is finalised, both the actors will keep their respective earnings from the projects they've worked on since November 2006.
Holmes is also likely to receive $3 million for every year she was married to Cruise as well as the couple's $35 million Beverly Hills mansion, reports femalefirst.co.uk.
Since they did not stay married for 11 years, the pre-nuptial agreement states California community property laws won't apply to the divorce - which normally sees a couple's assets split 50/50.